Studio francese: i vaccinati COVID-19 morirebbero meno?

Già solo tener conto del bias del vaccinato-sano capovolge i risultati

DI (A. Donzelli)

Bibliografia dell’ articolo pubblicato sul n. 163 de L’altra medicina magazine

1. Donzelli A. I vaccinati COVID-19 morirebbero meno? Attenti alle bufale! LAM 159/2026.
2. Semenzato L, Le Vu S, Botton J, et al. COVID-19 mRNA Vaccination and 4-Year All-Cause Mortality Among Adults Aged 18 to 59 Years in France. JAMA Netw Open. 2025 Dec 1;8(12):e2546822. doi: 10.1001/jamanetworkopen.2025.46822.
3. Alessandria M, et al. A Critical Analysis of All-Cause Deaths during COVID-19 Vaccination in an Italian Province. Microorganisms. 2024 Jun 30;12(7):1343. doi: 10.3390/microorganisms12071343.
4. Coronary Drug Project Research Group. Influence of adherence to treatment and response of cholesterol on mortality in the Coronary Drug Project. N. Engl. J. Med. 1980, 303, 1038–1041. [Google Scholar] [CrossRef] [PubMed]
5. Horwitz RI, Viscoli CM, Berkman L, et al. Treatment adherence and risk of death after a myocardial infarction. Lancet 1990, 336, 542–545. [Google Scholar] [CrossRef]
6. Granger BB, Swedberg K, Ekman I, et al CHARM investigators. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: Double-blind, randomised, controlled clinical trial. Lancet 2005, 366, 2005–2011. [Google Scholar] [CrossRef] [PubMed]
7. Simpson SH, Eurich DT, Majumdar SR, et al. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ 2006, 333, 15. [Google Scholar] [CrossRef]
8. Jackson LA, Jackson ML, Nelson JC, et al. (2006). Evidence of bias in estimates of influenza vaccine effectiveness in seniors. International Journal of Epidemiology, 35(2), 337-344. [Google Scholar] [CrossRef] [PubMed]
9. Simonsen L, Taylor RJ, Viboud C, et al. Mortality benefits of influenza vaccination in elderly people: an ongoing controversy. Lancet Infect Dis 2007; 7:658–66. DOI:10.1016/S0140-6736(07)61389-0.
10. Pinsky PF, Miller A, Kramer BS, et al. Evidence of a healthy volunteer effect in the prostate, lung, colorectal, and ovarian cancer screening trial. Am. J. Epidemiol. 2007, 165, 874–881. [Google Scholar] [CrossRef] [PubMed]
11. Vestbo J, Anderson JA, Calverley PM, et al. Adherence to inhaed therapy, mortality and hospital admission in COPD. Thorax 2009, 64, 939–943. [Google Scholar] [CrossRef] [PubMed]
12. Hottes TS, Skowronski DM, Hiebert B, et al. Influenza vaccine effectiveness in the elderly based on administrative databases: Change in immunization habit as a marker for bias. PLoS ONE 2011, 6, e22618. [Google Scholar] [CrossRef] [PubMed]
13. McCarthy NL, Weintraub E, Vellozzi C, et al. Mortality rates and cause-of-death patterns in a vaccinated population. Am. J. Prev. Med. 2013, 45, 91–97. [Google Scholar] [CrossRef]
14. Ladova K, Vlcek J, Vytrisalova M, Maly J. Healthy adherer effect—The pitfall in the interpretation of the effect of medication adherence on health outcomes. J. Eval. Clin. Pract. 2014, 20, 111–116. [Google Scholar] [CrossRef]
15. Remschmidt C, Wichmann O, Harder T. Frequency and impact of confounding by indication and healthy vaccinee bias in observational studies assessing influenza vaccine effectiveness: A systematic review. BMC Infect. Dis. 2015, 15, 429. [Google Scholar] [CrossRef] [PubMed]
16. Furst(a) T, Straka R, Janosek J. Healthy vaccinee effect: A bias not to be forgotten in observational studies on COVID-19 vaccine effectiveness. Pol. Arch. Intern. Med. 2024, 134, 16634. [Google Scholar] [CrossRef]
17. Fürst(b) T, Bazalová A, Fryčák T, Janošek J. Does the healthy vaccinee bias rule them all? Association of COVID-19 vaccination status and all-cause mortality from an analysis of data from 2.2 million individual health records. Int. J. Infect. Dis. 2024, 142, 106976. [Google Scholar] [CrossRef]
18. Riedmann U, Chalupka A, Richter L, et al. Underlying health biases in previously-infected SARS-CoV-2 vaccination recipients: A cohort study.J Infection, 2025; 90.
19. Chemaitelly H, Ayoub HH, Coyle P, et al. Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar. Elife. 2025;14:e103690.

20. Cai M, Xie Y, Al-Aly Z. 2024-2025 COVID-19 Vaccine and Major Adverse Cardiovascular Events Among US Veterans. JAMA Intern Med. 2026 Jun 15:e261929. doi: 10.1001/jamainternmed.2026.1929. Epub ahead of print. [è un chiaro esempio di ricerca che non considera il bias del vaccinato-sano]

• Redelmeier DA, Wang J, Thiruchelvam D. COVID Vaccine Hesitancy and Risk of a Traffic Crash. Amer J Medicine 2023;136:153-162. doi.org/10.1016/j.amjmed.2022.11.002. [con involontaria ironia (v. slide), gli autori suggeriscono che le assicurazioni autoveicolari tengano conto dello stato vaccinale degli assicurati]
• Ebrahimi Kalan M, Jebai R, Li W, et al. COVID-19 and tobacco products use among US adults, 2021 National Health Interview Survey. Health Sci Rep. 2023;6(9): e1542. doi: 10.1002/hsr2.1542. [la grottesca raccomandazione degli autori (v. slide) va a parare suglisforzi per promuovere la vaccinazione, in particolare tra chi usa prodotti del tabacco!]
• Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years’ observations on male

British doctors. BMJ, 2004. doi:10.1136/bmj.38142.554479.AE.

• Banks E, Joshy G, … Beral V. Tobacco smoking and all-cause mortality in a large Australian cohort study: findings from a mature epidemic with current low smoking prevalence. BMC Med. 2015 Feb 24;13:38. doi: 10.1186/s12916-015-0281-z.
• Donzelli A. Newsletter NoGrazie 125/luglio 2024 https://facebook.com/pages/NoGraziePagoIo/180764791950999 // O 137/sett. 2025 lettera@nograzie.eu
• Donzelli A. Efficacia e sicurezza dei vaccini COVID-19 gonfiate per un’illusione statistica che ha ingannato il mondo. LAM 155/…………. 2026.